A positive allosteric modulator of AMPA receptors
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Farampator

Item No. 21510

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,1,3-benzoxadiazol-5-yl-1-piperidinyl-methanone
CAS Number
211735-76-1
Synonyms
  • CX-691
Molecular Formula
C12H13N3O2
Formula Weight
231.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH7.2) (1:40): 25µg/mlDMSO: 20 mg/ml
λmax
295 nm
SMILES
O=C(C1=CC2=NON=C2C=C1)N3CCCCC3
InChi Code
InChI=1S/C12H13N3O2/c16-12(15-6-2-1-3-7-15)9-4-5-10-11(8-9)14-17-13-10/h4-5,8H,1-3,6-7H2
InChi Key
XFVRBYKKGGDPAJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $44

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    5 mg

    $198

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    10 mg

    $329

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    Product Description

    Farampator is a positive allosteric modulator of AMPA receptors that has an EC50 value greater than 32 µM for evoking glutamate currents in isolated pyramidal neurons.1 In rats, it enhances novel object recognition memory (0.1 mg/kg, p.o.) and attentional set-shifting (0.3 mg/kg, p.o.) and reverses a scopolamine-induced deficit in cued fear conditioning (0.1 mg/kg, p.o.).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Menniti, F.S., Lindsley, C.W., Conn, P.J., et al. Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks. Curr. Top. Med. Chem. 13(1), 26-54 (2013).

    2. Woolley, M.L., Waters, K.A., Garlton, J.E., et al. Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat. Psychopharmacol.(Berl). 202(1-3), 343-354 (2009).