A modulator of annexin A7
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ABO (hydrochloride)

Item No. 21515

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-amino-3,4-dihydro-2H-1,4-benzoxazine-3-methanol, dihydrochloride
CAS Number
2309172-24-3
Molecular Formula
C9H12N2O2 • 2HCl
Formula Weight
253.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
212, 255, 306 nm
SMILES
NC1=CC=C(OCC(CO)N2)C2=C1.Cl.Cl
InChi Code
InChI=1S/C9H12N2O2.2ClH/c10-6-1-2-9-8(3-6)11-7(4-12)5-13-9;;/h1-3,7,11-12H,4-5,10H2;2*1H
InChi Key
WQHCJHKXKVXAEW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $153

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    25 mg

    $336

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    Product Description

    ABO is a modulator of annexin A7.1 It binds to Thr286 and inhibits phosphorylation of annexin A7 at threonine, but not serine or tyrosine, residues in human umbilical vein endothelial cells (HUVECs). ABO enhances the interaction between annexin A7 and the EF-hand protein GCA, decreases GCA phosphorylation as well as intracellular calcium concentration, and promotes autophagy in COS-7 cells. It also decreases phosphorylation of microtubule-associated protein 1 light chain (LC3) in HUVECs and suppresses oxidized low-density lipoprotein-induced increases in phosphatidylcholine-specific phospholipase C (PC-PLC) expression in vascular endothelial cells (VECs).1,2 In vivo, ABO (50 or 100 mg/kg per day) decreases PC-PLC levels, enhances autophagy, and reduces apoptosis, lipid deposition, and atherosclerotic plaque area in the aortic endothelium of apoE-/- mice fed a Western diet.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, H., Liu, N., Wang, S., et al. Identification of a small molecule targeting annexin A7. Biochim. Biophys. Acta 1883(9), 2092-2099 (2013).

    2. Li, H., Huang, S., Wang, S., et al. Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine-specific phospholipase C in vascular endothelial cells and inhibited atherosclerosis in apolipoprotein E⁻/⁻mice. Cell Death Dis. 4, e806 (2013).