A positive allosteric modulator of δ-opioid receptors
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BMS 986188

Item No. 21548

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-[4-[(2-bromophenyl)methoxy]phenyl]-3,4,5,6,7,9-hexahydro-3,3,6,6-tetramethyl-1H-xanthene-1,8(2H)-dione
CAS Number
1776115-10-6
Molecular Formula
C30H31BrO4
Formula Weight
535.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1mg/mLDMF:PBS (pH 7.2) (1:2): 0.3mg/mLDMSO: slightly solubleEthanol: slightly soluble
λmax
223, 286 nm
SMILES
BrC1=C(COC2=CC=C(C3C(C(CC(C)(C)C4)=O)=C4OC(CC(C)(C)C5)=C3C5=O)C=C2)C=CC=C1
InChi Code
InChI=1S/C30H31BrO4/c1-29(2)13-22(32)27-24(15-29)35-25-16-30(3,4)14-23(33)28(25)26(27)18-9-11-20(12-10-18)34-17-19-7-5-6-8-21(19)31/h5-12,26H,13-17H2,1-4H3
InChi Key
BBCHHZHONQIODT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $106

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    10 mg

    $197

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    Product Description

    BMS 986188 is a positive allosteric modulator of δ-opioid receptors, with an EC50 value of 0.05 μM in a β-arrestin recruitment assay in the presence, but not absence, of the opioid receptor agonist leu-enkephalin (Item No. 23283).1 It is selective for δ- over μ-opioid receptors (EC50 = >10 μM) in the presence of leu-enkephalin and the μ-opioid receptor agonist endomorphin 1 (Item No. 23280), respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burford, N.T., Livingston, K.E., Canals, M., et al. Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. J. Med. Chem. 58(10), 4220-4229 (2015).