Alda-1

Alda-1 is a selective aldehyde dehydrogenase 2 (ALDH2) agonist.¹ This cell-permeable benzamide selectively enhances the activity of WT ALDH2*1 and the East Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2-, and 11-fold increase in V_max of 20 µg homozygous WT, heterozygous WT/mutant, and homozygous mutant tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Alda-1 (20 µM) protects against ex vivo ischemic tissue damage to excised rat hearts (25% and 24% reduction in infarct size and creatine phosphokinase (CPK) release, respectively).² Alda-1 also, at a dose of 8.5 mg/kg, reduces infarct size by 60% in anesthetized live rats.

WARNING This product is not for human or veterinary use.

1. Perez-Miller, S., Younus, H., Vanam, R., et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nat. Struct. Mol. Biol. 17(2), 159-164 (2010).

2. Chen, C.-H., Budas, G.R., Churchill, E.N., et al. An activator of mutant and wildtype aldehyde dehydrogenase reduces ischemic damage to the heart. Science 321(5895), 1493-1495 (2008).