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Walrycin B

Item № 21566
CAS № 878419-78-4
Purity ≥98%
product image
                (CAS 878419-78-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $29.00 0.00
     5 mg $138.00 0.00
     10 mg $261.00 0.00
     25 mg $580.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description

Walrycin B is an antibiotic that has activity against Gram-positive bacteria (MICs = 0.39 and 3.13 μg/ml for B. subtilis and S. aureus, respectively) via inhibition of WalR, a response regulator that is essential to bacterial viability.1 It inhibits WalR-induced repression of EGFP signaling in a reporter assay in a concentration-dependent manner. Walrycin B alters expression of WalR regulon genes, decreasing ydjM, yocH, and ycvE and increasing yoeB and yjeA expression in B. subtilis. It also halts transcription of isaA and ssaA in S. aureus. Overexpression of WalR induces a 4- and 2-fold increase in the MIC against B. subtilis and S. aureus, respectively, indicating cell death is induced specifically through inhibition of WalR by walrycin B.

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Technical Information
Formal Name
1,6-dimethyl-3-[4-(trifluoromethyl)phenyl]-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione
CAS Number
878419-78-4
Molecular Formula
C14H10F3N5O2
Formula Weight
337.3
Purity
≥98%
Formulation
A crystalline solid
λmax
291, 416 nm
SMILES
CN1C(C(C(N2C)=O)=NC(C3=CC=C(C(F)(F)F)C=C3)=N1)=NC2=O
InChI Code
InChI=1S/C14H10F3N5O2/c1-21-12(23)9-11(19-13(21)24)22(2)20-10(18-9)7-3-5-8(6-4-7)14(15,16)17/h3-6H,1-2H3
InChI Key
XRVMPTWWKLKLPB-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Gotoh, Y., Doi, A., Furuta, E., et al. Novel antibacterial compounds specifically targeting the essential WalR response regulator J. Antibiot. (Tokyo) 63(3), 127-134 (2010).

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