A selective STAT3 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

HO-3867

Item No. 21581

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3E,5E)-1-[(2,5-dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-4-piperidinone
CAS Number
1172133-28-6
Molecular Formula
C28H30F2N2O2
Formula Weight
464.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:2): 0.33 mg/mlDMSO: 10 mg/mlEthanol: slightly soluble
λmax
229, 324 nm
SMILES
FC1=CC=C(/C=C2CN(CC3=CC(C)(C)N(O)C3(C)C)C/C(C\2=O)=C\C4=CC=C(F)C=C4)C=C1
InChi Code
InChI=1S/C28H30F2N2O2/c1-27(2)15-23(28(3,4)32(27)34)18-31-16-21(13-19-5-9-24(29)10-6-19)26(33)22(17-31)14-20-7-11-25(30)12-8-20/h5-15,34H,16-18H2,1-4H3/b21-13+,22-14+
InChi Key
PWZQFTQMMAIRRM-JFMUQQRKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $63

    Add

    5 mg

    $255

    Add

    10 mg

    $481

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    HO-3867 is an analog of curcumin (Item No. 81025) that selectively suppresses STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.1,2 It has been shown to induce apoptosis in BRCA-mutated ovarian cancer cells with minimal toxicity to normal cells.2,3 HO-3867 is reported to demonstrate synergistic inhibition of chemotherapy-resistant ovarian xenograft tumors when combined with cisplatin (Item No. 13119).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Selvendiran, K., Ahmed, S., Dayton, A., et al. HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition. Cancer Biol. Ther. 12(9), 837-845 (2011).

    2. Rath, K.S., Naidu, S.K., Lata, P., et al. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res. 74(8), 2316-2327 (2014).

    3. Tierney, B.J., McCann, G.A., Cohn, D.E., et al. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer Biol. Ther. 13(9), 766-775 (2012).