An acetyl derivative of spermidine
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Product Type

Biochemicals

Research Area

Cancer

N1,N8-Diacetylspermidine (hydrochloride)

Item No. 21588

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[3-(acetylamino)propyl]amino]butyl]-acetamide, monohydrochloride
CAS Number
178244-42-3
Synonyms
  • NSC 685959
Molecular Formula
C11H23N3O2 • HCl
Formula Weight
265.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC(NCCCCNCCCNC(C)=O)=O.Cl
InChi Code
InChI=1S/C11H23N3O2.ClH/c1-10(15)13-8-4-3-6-12-7-5-9-14-11(2)16;/h12H,3-9H2,1-2H3,(H,13,15)(H,14,16);1H
InChi Key
RWKXLCKGDFFGNU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    5 mg

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    10 mg

    $466

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    25 mg

    $895

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    Cayman Chemical
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    Product Description

    N1,N8-Diacetylspermidine is a diacetylated derivative of spermidine (Item No. 14918), a natural polyamine.1,2 N1,N8-Diacetylspermidine has been found in human urine and is elevated in the urine of patients with colorectal and urogenital malignancies. It is selectively elevated in those with malignant conditions over those with benign urogenital hyperplasias, making this polyamine a potential biomarker for cancer detection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hiramatsu, K., Sugimoto, M., Kamei, S., et al. Diagnostic and prognostic usefulness of N1,N8-diacetylspermidine and N1,N12-diacetylspermine in urine as novel markers of malignancy. J. Cancer Res. Clin. Oncol. 123(10), 539-545 (1997).

    2. Kawakita, M., and Hiramatsu, K. Diacetylated derivatives of spermine and spermidine as novel promising tumor markers. J. Biochem. 139(3), 315-322 (2006).