A short-chain acyl CoA
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n-Propionyl-Coenzyme A (lithium salt)

Item No. 21603

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
coenzyme A, S-propanoate, lithium salt
CAS Number
108321-21-7
Synonyms
  • n-Propionyl-CoA
Molecular Formula
C24H39N7O17P3S • XLi
Formula Weight
829.5
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Sparingly Soluble: 1-10 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP([O-])(O)=O.[Li+]
InChi Code
InChI=1S/C24H40N7O17P3S.Li/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31;/h11-13,17-19,23,34-35H,4-10H2,1-3H3,(H,26,32)(H,27,36)(H,40,41)(H
InChi Key
NHDDMVHJPMKFOA-IEQRABFGSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    n-Propionyl-coenzyme A (n-propionyl-CoA) is a derivative of CoA (Item Nos. 16147 | 21499 | 21722) that contains the short-chain fatty acid propionic acid. It is formed primarily by metabolism of essential amino acids and through β-oxidation of odd-chain fatty acids.1 It accumulates in propionic acidemia, an autosomal recessive disorder characterized by non-functional propionyl-CoA carboxylase (PCC), the enzyme that catabolizes n-propionyl-CoA to methylmalonyl-CoA (Item No. 23551). n-Propionyl-CoA is also a precursor in the synthesis of D-α-hydroxyglutaric acid (Item Nos. 25895 | 11605) in bacteria.2 n-Propionyl-CoA has been used as an internal recovery standard for the quantification of HMG-CoA (Item No. 25394) by HPLC.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Scholl-Bürgi, S., Zschocke, J., and Karall, D. Amino acid metabolism in patients with propionic acidaemia. J. Inherit. Metab. Dis. 35(1), 65-70 (2012).

    2. Reeves, H.C., and Ajl, S.J. Alpha-hydroxyglutaric acid synthetase. J. Bacteriol. 84(1), 186-187 (1962).

    3. Honda, A., Salen, G., Nguyen, L.B., et al. Regulation of early cholesterol biosynthesis in rat liver: Effects of sterols, bile acids, lovastatin, and BM 15.766 on 3-hydroxy-3-methylglutaryl coenzyme A synthase and acetoacetyl coenzyme A thiolase activities. Hepatology 27(1), 154-159 (1998).