A P-type calcium channel blocker
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ω-Agatoxin IVA (trifluoroacetate salt)

Item No. 21605

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
ω-agatoxin IVA, 2,2,2-trifluoroacetate
Synonyms
  • ω-Aga IVa
  • SNX-290
Molecular Formula
C217H360N68O60S10 • CF3COOH
Formula Weight
5316.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(NCC(NCC(N[C@]([C@@H](C)O)([H])C(N1CCC[C@H]1C(N[C@H](C2=O)CSSC[C@H](N3)C(N[C@@H](CCCCN)C(N4CCC[C@H]4C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)C)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O)=O)CSSC[C@H](N7)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CO)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(N)=O)C8=O)=O)=O)=O)CCSC)=O)=O)=O)CSSC[C@H](N8)C(N[C@@H](CCC(O)=O)C3=O)=O)=O)=O)=O)=O)=O)CC9=CC=C(O)C=C9)=O)CC(O)=O)=O)=O)C)=O)=O)CSSC[C@H](N2)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCNC(N)=N)C(NCC7=O)=O)=O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C217H360N68O60S10.C2HF3O2/c1-21-111(11)168-206(337)247-115(15)174(305)254-128(48-28-34-70-219)185(316)268-144(89-167(303)304)193(324)266-141(86-119-59-61-121(289)62-60-119)181(312)246-94-159(293)250-127(55-41-77-236-216(230)231)183(314)271-147-101-349-348-100-146-202(333)283-171(114(14)24-4)209(340)277-152-106-354-350-102-148(274-192(323)143(88-156(225)290)269-210(341)172(117(17)287)278-164(298)98-244-179(310)135(67-81-346-19)262-207(338)170(113(13)23-3)281-195(326)145(99-286)270-200(152)331)198(329)260-134(64-66-166(301)302)189(320)272-150(199(330)264-137(52-32-38-74-223)211(342)284-79-43-57-154(284)204(335)261-132(56-42-78-237-217(232)233)187(318)265-140(85-110(9)10)194(325)280-169(112(12)22-2)208(339)263-136(68-82-347-20)190(321)259-133(63-65-165(299)300)178(309)243-95-160(294)251-138(83-108(5)6)180(311)245-96-161(295)252-139(84-109(7)8)191(322)248-116(16)213(344)345)104-352-353-105-151(276-205(336)155-58-44-80-285(155)212(343)173(118(18)288)279-163(297)92-239-157(291)91-240-182(313)142(87-120-90-238-124-47-26-25-45-122(120)124)267-186(317)130(258-197(147)328)50-30-36-72-221)201(332)275-149(196(327)256-126(54-40-76-235-215(228)229)177(308)242-93-158(292)249-125(53-39-75-234-214(226)227)176(307)241-97-162(296)253-146)103-351-355-107-153(203(334)282-168)273-188(319)131(51-31-37-73-222)257-184(315)129(49-29-35-71-220)255-175(306)123(224)46-27-33-69-218;3-2(4,5)1(6)7/h25-26,45,47,59-62,90,108-118,123,125-155,168-173,238,286-289H,21-24,27-44,46,48-58,63-89,91-107,218-224H2,1-20H3,(H2,225,290)(H,239,291)(H,240,313)(H,241,307)(H,242,308)(H,243,309)(H,244,310)(H,245,311)(H,246,312)(H,247,337)(H,248,322)(H,249,292)(H,250,293)(H,251,294)(H,252,295)(H,253,296)(H,254,305)(H,255,306)(H,256,327)(H,257,315)(H,258,328)(H,259,321)(H,260,329)(H,261,335)(H,262,338)(H,263,339)(H,264,330)(H,265,318)(H,266,324)(H,267,317)(H,268,316)(H,269,341)(H,270,331)(H,271,314)(H,272,320)(H,273,319)(H,274,323)(H,275,332)(H,276,336)(H,277,340)(H,278,298)(H,279,297)(H,280,325)(H,281,326)(H,
InChi Key
DQSAHIRUVHYDFU-MWIVDHNXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

    $569

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    Product Description

    ω-Agatoxin IVA is a natural peptide first isolated from the venom of funnel spiders.1 It selectively and irreversibly blocks P-type calcium channels (IC50 <1 nM), high voltage-activated channels first discovered in Purkinje cells.2,3 ω-Agatoxin IVA also blocks N-type calcium channels at micromolar concentrations.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mintz, I.M., Venema, V.J., Swiderek, K.M., et al. P-type calcium channels blocked by the spider toxin omega-Aga-IVA. Nature 355(6363), 827-829 (1992).

    2. Mori, Y., Mikala, G., Varadi, G., et al. Molecular pharmacology of voltage-dependent calcium channels. Jpn. J. Pharmacol. 72(2), 83-109 (1996).

    3. Tringham, E.W., Dupere, J.R.B., Payne, C.E., et al. Protease treatment of cerebellar Purkinje cells renders ω-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by ω-conotoxin GVIA. J. Pharmacol. Exp. Ther. 324(2), 806-814 (2008).