An agonist at AT1 and AT2 receptors
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Angiotensin III (human, mouse)

Item No. 21618

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-L-isoleucine-2-8-angiotensin II
CAS Number
13602-53-4
Molecular Formula
C46H66N12O9
Formula Weight
931.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
SMILES
C[C@@H](CC)[C@]([H])(NC([C@@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)N)=O)=O)CC1=CC=C(C=C1)O)=O)C(N[C@@H](CC2=CNC=N2)C(N3[C@H](C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)CCC3)=O)=O
InChi Code
InChI=1S/C46H66N12O9/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28/h6-8,11-12,15-18,24-27,3
InChi Key
QMMRCKSBBNJCMR-KMZPNFOHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $68

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    25 mg

    $128

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    50 mg

    $236

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    Product Description

    Angiotensin III (Ang III) is a heptapeptide agonist at the angiotensin 1 (AT1) and AT2 receptors, with a 30-fold higher affinity for AT2 compared with AT1 in HEK293 cells.1,2 Ang III is the preferred agonist for renal AT2 receptors, which are responsible for sodium excretion into the urine.3 Ang III induces the same level of aldosterone synthesis as Ang II but has lower vasoconstrictive activity in vivo.4 In the brain renin-angiotensin system, Ang III increases sympathetic nerve activity and vasopressin release and dampens the baroreflex leading to higher blood pressure.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bosnyak, S., Jones, E.S., Christopoulos, A., et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin. Sci. (Lond.) 121(7), 297-303 (2011).

    2. Wright, J.W., and Harding, J.W. Brain renin-angiotensin--a new look at an old system. Prog. Neurobiol. 95(1), 49-67 (2011).

    3. Kemp, B.A., Bell, J.F., Rottkamp, D.M., et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension 60(2), 387-395 (2012).

    4. Blair-West, J.R., Coghlan, J.P., Denton, D.A., et al. A dose-response comparison of the actions of angiotensin II and angiotensin III in sheep. J. Endocrinol. 87(3), 409-417 (1980).

    5. Gao, J., Marc, Y., Iturrioz, X., et al. A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. Clin. Sci. (Lond.) 127(3), 135-148 (2014).