A randomly methylated form of β-cyclodextrin
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Product Categories

Product Type

Biochemicals

Research Area

Lipid Biochemistry
Neuroscience

Methyl-β-cyclodextrin

Item No. 21633

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
β-cyclodextrin, methyl ethers
CAS Number
128446-36-6
Synonyms
  • Randomly methylated β-cyclodextrin
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF: 30 mg/mLDMSO: 30 mg/mLDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol: 30 mg/mLPBS (pH 7.2): 10 mg/mLPBS (pH 7.2): 10 mg/ml
SMILES
C[C@@H]1[C@@H](O[R])O[C@H](O[C@@H]2[C@@H](O[R])O[C@H](O[C@@H]3[C@@H](O[R])O[C@H](O[C@@H]4[C@@H](O[R])O[C@H](O[C@@H]5[C@@H](O[R])O[C@H](O[C@@H]6[C@@H](O[R])O[C@H](O[C@@H]7[C@@H](O[R])O[C@H](OC)[C@H](O[R])[C@H]7O[R])[C@H](O[R])[C@H]6O[R])[C@H](O[R])[C@H]5O[R])[C@H](O[R])[C@H]4O[R])[C@H](O[R])[C@H]3O[R])[C@H](O[R])[C@H]2O[R])[C@H](O[R])[C@H]1O[R]
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

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    Product Description

    Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin (Item No. 23387).1 Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes.1,2 Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein.3 It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Katageri, A.R., and Sheikh, M.A. Cyclodextrin a gift to pharmaceutical world review. Int. Res. J. Pharm. 3(1), 52-56 (2012).

    2. Besenicar, M.P., Bavdek, A., Kladnik, A., et al. Kinetics of cholesterol extraction from lipid membranes by methyl-β-cyclodextrin--a surface plasmon resonance approach. Biochim. Biophys. Acta 1778(1), 175-184 (2008).

    3. Bar-On, P., Rockenstein, E., Adame, A., et al. Effects of the cholesterol-lowering compound methyl-β-cyclodextrin in models of α-synucleinopathy. J. Neurochem. 98(4), 1032-1045 (2006).