A selective TRPM8 antagonist
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M8-B (hydrochloride)

Item No. 21646

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide, monohydrochloride
CAS Number
883976-12-3
Molecular Formula
C22H24N2O3S • HCl
Formula Weight
433.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 15 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
235, 276 nm
SMILES
COC(C=C(CN(C(C1=CC=CS1)=O)CCN)C=C2)=C2OCC3=CC=CC=C3.Cl
InChi Code
InChI=1S/C22H24N2O3S.ClH/c1-26-20-14-18(9-10-19(20)27-16-17-6-3-2-4-7-17)15-24(12-11-23)22(25)21-8-5-13-28-21;/h2-10,13-14H,11-12,15-16,23H2,1H3;1H
InChi Key
FMQJBHACRTZLME-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $153

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    25 mg

    $336

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    Product Description

    M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin (Item No. 10137), or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively).1 It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Almeida, M.C., Hew-Butler, T., Soriano, R.N., et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J. Neurosci. 32(6), 2086-2099 (2012).