Moroxydine (hydrochloride)

Moroxydine is a heterocyclic biguanidine compound with antiviral activity. In grass carp reovirus-infected CIK cells, virus-related Bcl-2- and caspase-mediated apoptosis is reduced by 50% following treatment with 6.3 µg/ml of moroxydine for 96 hours.¹ Moroxydine targets DNA and RNA viruses including measles, herpes simplex, varicella zoster, and hepatitis C, and formulations containing moroxydine are used to treat the symptoms of influenza virus strain A infection.^1,2,3 Moroxydine is considered effective and generally safe in veterinary applications. In gibel carp housed at 25°C, the absorption and elimination half-lives are 2.02 and 4.22 hours, respectively, following oral administration of a 10 mg/kg dose of moroxydine.⁴

WARNING This product is not for human or veterinary use.

1. Yu, X.-B., Chen, X.-H., Ling, F., et al. Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Res. 131, 156-165 (2016).

2. Hopkins, E.J., Pye, A.M., Solomon, M., et al. Controlled trial of "virugon" in treatment of measles. Br. Med. J. 2(5262), 1263-1264 (1961).

3. Brown, A.G., Renton, G.H., and Griffiths, P. Comparative study of "Virugon" and penicillin in measles. Br. Med. J. 1(5275), 374-375 (1962).

4. Liu, W., Xu, J., Zhou, Y., et al. Pharmacokinetics and tissue residues of moroxydine hydrochloride in gibel carp, Carassius gibelio after oral administration. J. Vet. Pharmacol. Ther. 39(4), 398-404 (2016).