A KLF5 inhibitor
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CID-5951923

Item No. 21649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(3-nitrophenyl)-2-propenoic acid, 2-[methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl ester
CAS Number
749872-43-3
Molecular Formula
C16H18N2O7S
Formula Weight
382.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 16 mg/ml
λmax
260 nm
SMILES
O=C(OCC(N(C)C1CS(CC1)(=O)=O)=O)/C=C/C2=CC=CC([N+]([O-])=O)=C2
InChi Code
InChI=1S/C16H18N2O7S/c1-17(14-7-8-26(23,24)11-14)15(19)10-25-16(20)6-5-12-3-2-4-13(9-12)18(21)22/h2-6,9,14H,7-8,10-11H2,1H3/b6-5+
InChi Key
URVRJYLSUVXWBC-AATRIKPKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $153

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    25 mg

    $336

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    Cayman Chemical
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    Product Description

    CID-5951923 is an inhibitor of the transcription factor Krüppel-like factor 5 (KLF5; IC50 = 2.3 μM).1 It decreases KLF5 expression in and reduces growth of DLD-1 colorectal adenocarcinoma cells in a concentration-dependent manner. CID-5951923 selectively inhibits proliferation of cancer cell lines that highly express KLF5, particularly colon adenocarcinomas, in the NCI-60 panel of cancer cell lines.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bialkowska, A.B., Crisp, M., Bannister, T., et al. Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening. Mol. Cancer Ther. 10(11), 2043-2051 (2011).