An activator of EAAT2
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LDN-0212320

Item No. 21650

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[(2-methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine
CAS Number
894002-50-7
Synonyms
  • OSU-0212320
Molecular Formula
C17H15N3S
Formula Weight
293.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/mLEthanol: 5 mg/mL
λmax
294 nm
SMILES
CC1=CC=CC=C1CSC(N=N2)=CC=C2C3=CC=CC=N3
InChi Code
InChI=1S/C17H15N3S/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15/h2-11H,12H2,1H3
InChi Key
DUUQLWDHNYFUPP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $120

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    25 mg

    $263

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    50 mg

    $461

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    Product Description

    LDN-0212320 is an activator of excitatory amino acid transporter 2 (EAAT2) that increases expression of EAAT2 in PA-EAAT2 cells in a concentration- and time-dependent manner (EC50 = 1.83 μM).1 It selectively increases EAAT2 protein levels over EAAT1 and EAAT3 protein levels and increases glutamate uptake in primary dissociated neuron and astrocyte mixed cultures when used at concentrations ranging from 1 to 3 μM. LDN-0212320 (3 μM) decreases neuronal loss and degeneration in primary dissociated neuron and astrocyte mixed cultures. In vivo, LDN-0212320 (40 mg/kg, i.p.) increases EAAT2 protein levels and glutamate uptake in mouse forebrain. It also delays motor function decline and increases lifespan in the SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kong, Q., Chang, L.-C., Takahashi, K., et al. Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection. J. Clin. Invest. 124(3), 1255-1267 (2014).