An inhibitor of PNP
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9-Deazaguanine

Item No. 21674

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
CAS Number
65996-58-9
Synonyms
  • NSC 344522
Molecular Formula
C6H6N4O
Formula Weight
150.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: slightly solublePBS (pH 7.2): slightly soluble
λmax
229, 260 nm
SMILES
NC(N1)=NC2=C(NC=C2)C1=O
InChi Code
InChI=1S/C6H6N4O/c7-6-9-3-1-2-8-4(3)5(11)10-6/h1-2,8H,(H3,7,9,10,11)
InChi Key
FFYPRJYSJODFFD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $127

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    25 mg

    $280

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    50 mg

    $525

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    Cayman Chemical
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    Product Description

    9-Deazaguanine is an analog of guanine that acts as an inhibitor of purine nucleoside phosphorylase (PNP; Kd = 160 nM).1 Inhibitors of PNP are used to control T cell proliferation, particularly in T cell cancers, autoimmune diseases, and tissue transplant rejection.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wielgus-Kutrowska, B., Breer, K., Hashimoto, M., et al. Trimeric purine nucleoside phosphorylase: Exploring postulated one-third-of-the-sites binding in the transition state. Bioorg. Med. Chem. 20(22), 6758-6769 (2012).

    2. Schramm, V.L. Development of transition state analogues of purine nucleoside phosphorylase as anti-T-cell agents. Biochim. Biophys. Acta 1587(2-3), 107-117 (2002).