A macrolide antibiotic
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Solithromycin

Item No. 21681

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-[4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
CAS Number
760981-83-7
Molecular Formula
C43H65FN6O10
Formula Weight
845.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2.5 mg/ml
λmax
233, 311 nm
SMILES
O=C(N1CCCCN2N=NC(C3=CC=CC(N)=C3)=C2)O[C@]([C@@]1([H])[C@H]4C)(C)[C@@H](CC)OC([C@@](C)(F)C([C@H](C)[C@@H](O[C@@]5([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O5)[C@](C)(OC)C[C@@H](C)C4=O)=O)=O
InChi Code
InChI=1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-
InChi Key
IXXFZUPTQVDPPK-ZAWHAJPISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Solithromycin is a macrolide antibiotic with activity against Gram-positive and Gram-negative bacteria, including C. trachomatis and C. pneumoniae (MICs = 0.125-0.5 and 0.25-1 μg/ml, respectively).1 It also inhibits growth of multidrug resistant P. falciparum in vitro (IC50s = 0.5 nM for both Dd2 and 7G8 strains).2 Solithromycin (100 mg/kg) administered in a four-dose series eradicates P. berghei infection in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roblin, P.M., Kohlhoff, S.A., Parker, C., et al. In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae. Antimicrob. Agents Chemother. 54(3), 1358-1359 (2010).

    2. Wittlin, S., Ekland, E.H., Craft, J.C., et al. In vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium species. Antimicrob. Agents Chemother. 56(2), 703-707 (2012).