A C3a receptor agonist
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C3a Receptor Agonist

Item No. 21683

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]-benzeneacetamide
CAS Number
944997-60-8
Molecular Formula
C27H35N3O2
Formula Weight
433.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH7.2) (1:7): 0.125 mg/ml
λmax
262 nm
SMILES
O=C(N1CCC(NC(C(C2CCCCC2)C3=CC=CC=C3)=O)CC1)CCC4=CC=CN=C4
InChi Code
InChI=1S/C27H35N3O2/c31-25(14-13-21-8-7-17-28-20-21)30-18-15-24(16-19-30)29-27(32)26(22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1,3-4,7-10,17,20,23-24,26H,2,5-6,11-16,18-19H2,(H,29,32)
InChi Key
RMFOYNMWESQGBZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $143

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    5 mg

    $634

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    Product Description

    Complement 3a (C3a) receptor agonist binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway.1 Activation of C3aR prevents neutrophils from being mobilized in a model of intestinal ischemia-reperfusion injury.2 C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. C3a stimulates differentiation of neural progenitor cells in vitro.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Klos, A., Wende, E., Wareham, K.J., et al. International union of basic and clinical pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol. Rev. 65(1), 500-543 (2013).

    2. Wu, M.C.L., Brennan, F.H., Lynch, J.P.L., et al. The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proc. Natl. Acad. Sci. USA 110923), 9439-9444 (2013).

    3. Rahpaymai, Y., Hietala, M.A., Wilhelmsson, U., et al. Complement: A novel factor in basal and ischemia-induced neurogenesis. EMBO J. 25(6), 1364-1374 (2006).

    4. Shinjyo, N., Ståhlberg, A., Dragunow, M., et al. Complement-derived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells. Stem Cells 27(11), 2824-2832 (2009).