An electron transport chain inhibitor
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Buparvaquone

Item No. 21704

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-(1,1-dimethylethyl)cyclohexyl]methyl]-3-hydroxy-1,4-naphthalenedione
CAS Number
88426-33-9
Synonyms
  • BW 720C
Molecular Formula
C21H26O3
Formula Weight
326.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 1 mg/mlEthanol: Slightly Soluble
λmax
252, 282, 332 nm
SMILES
OC1=C(CC2CCC(C(C)(C)C)CC2)C(C3=CC=CC=C3C1=O)=O
InChi Code
InChI=1S/C21H26O3/c1-21(2,3)14-10-8-13(9-11-14)12-17-18(22)15-6-4-5-7-16(15)19(23)20(17)24/h4-7,13-14,24H,8-12H2,1-3H3
InChi Key
KLLIVCPQDTYMLC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $41

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    50 mg

    $186

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    100 mg

    $351

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    250 mg

    $823

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    Product Description

    Buparvaquone is a hydroxynaphthoquinone that inhibits electron transport by blocking cytochrome bc1 in parasites that cause leishmaniasis.1 Formulations containing buparvaquone are used to treat theileriosis, an infection by the parasites T. annulata and T. parva (in vitro EC50s of 1.5 x 10-8 M and 6.1 x 10-10 M, respectively).2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ortiz, D., Forquer, I., Boitz, J., et al. Targeting the cytochrome bc1 complex of Leishmania parasites for discovery of novel drugs. Antimicrob. Agents and Chemother. 60(8), 4972-4982 (2016).

    2. Abdou, T.A., Abou-El-naga, T.R., and Mahmoud, M.A. Clinicopathological studies on Theileria annulata infection in Siwa oasis in Egypt. 56th Annual Meeting of the European Association for Animal Production 70 (2005).

    3. Hudson, A.T., Randall, A.W., Fry, M., et al. Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity. Parasitology 90(Pt 1), 45-55 (1985).