An inhibitor of tubulin polymerization
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MPT0B014

Item No. 21718

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-quinolinyl(3,4,5-trimethoxyphenyl)methanone
CAS Number
1215208-59-5
Molecular Formula
C19H17NO4
Formula Weight
323.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml
λmax
250 nm
SMILES
COC1=C(C=C(C(C2=CC(C=CC=N3)=C3C=C2)=O)C=C1OC)OC
InChi Code
InChI=1S/C19H17NO4/c1-22-16-10-14(11-17(23-2)19(16)24-3)18(21)13-6-7-15-12(9-13)5-4-8-20-15/h4-11H,1-3H3
InChi Key
GSGXITQZCMSYKF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $32

    Add

    5 mg

    $120

    Add

    10 mg

    $208

    Add

    25 mg

    $439

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    MPT0B014 is an inhibitor of tubulin polymerization.1 It inhibits proliferation of A549, H1299, and H226 human non-small cell lung cancer (NSCLC) cells (IC50s = 0.041, 0.046, and 0.041 µM, respectively), as well as adriamycin-resistant NCI/ADR cells that overexpress P-glycoprotein (IC50 = ~0.03 µM). MPT0B014 (0.3 µM) induces cell cycle arrest at the G2/M phase and apoptosis in A549 cells. It reduces tumor growth in an A549 mouse xenograft model when administered in combination with the EGFR tyrosine kinase inhibitor erlotinib (Item No. 10483).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsai, A.-C., Pai, H.-C., Wang, C.-Y., et al. In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells. Br. J. Pharmacol. 171(1), 122-133 (2014).