An essential cofactor in enzymatic acetyl transfer reactions
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Coenzyme A (sodium salt)

Item No. 21722

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
55672-92-9
Synonyms
  • CoA
Molecular Formula
C21H35N7O16P3S • XNa
Formula Weight
766.5
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
258 nm
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCS)=O)=O)(O)=O)(O)=O)[C@H]1OP([O-])(O)=O.[Na+]
InChi Code
InChI=1S/C21H36N7O16P3S.Na/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);/q;+1/p-1/t11-,14-,15-,16+,20-;/m1./s1
InChi Key
FPPFJMWMEFOUTR-BLPRJPCASA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $40

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    10 mg

    $60

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    25 mg

    $96

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    50 mg

    $171

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    Product Description

    Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism.1 About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid (Item No. 17288) in a five-step process that requires ATP.2 The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leonardi, R., Zhang, Y.M., Rock, C.O., et al. Coenzyme A: Back in action. Prog. Lipid Res. 44(2-3), 125-153 (2005).

    2. Jackowski, S. Biosynthesis of pantothenic acid and coenzyme A. Escherichia coli and Salmonella typhimurium: Cellular and molecular biology 687-694 (1996).

    3. Begley, T.P., Kinsland, C., and Strauss, E. The biosynthesis of coenzyme A in bacteria. Vitam. Horm. 61, 157-171 (2001).