An inhibitor of SAAH
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D-Eritadenine

Item No. 21747

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-amino-αR,βR-dihydroxy-9H-purine-9-butanoic acid
CAS Number
23918-98-1
Molecular Formula
C9H11N5O4
Formula Weight
253.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
1N HCl: slightly soluble
λmax
210, 261 nm
SMILES
NC1=NC=NC2=C1N=CN2C[C@@H](O)[C@@H](O)C(O)=O
InChi Code
InChI=1S/C9H11N5O4/c10-7-5-8(12-2-11-7)14(3-13-5)1-4(15)6(16)9(17)18/h2-4,6,15-16H,1H2,(H,17,18)(H2,10,11,12)/t4-,6-/m1/s1
InChi Key
LIEMBEWXEZJEEZ-INEUFUBQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $51

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    $203

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    10 mg

    $329

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    Cayman Chemical
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    Product Description

    D-Eritadenine is an adenosine analog and a potent, reversible inhibitor of S-adenosylhomocysteine hydrolase (SAAH; IC50 = 7 nM).1 It inhibits growth of C. parvum parasites (MIC50 = 3 μM) without exhibiting cytotoxicity in HCT-8 cells (CC50 = >1 mM).2 Dietary administration of D-eritadenine (50 mg/kg) increases liver microsomal phosphatidylethanolamine concentration and decreases liver microsomal Δ6 desaturase activity and plasma cholesterol levels in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, Y., Komoto, J., Takata, Y., et al. Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine. The Journal of Biological Chemisty 277(9), 7477-7482 (2002).

    2. Ctrnáctá, V., Fritzler, J.M., Surinová, M., et al. Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro. Exp. Parasitol. 126(2), 113-116 (2010).

    3. Shimada, Y., Yamakawa, A., Morita, T., et al. Effects of dietary eritadenine on the liver microsomal Δ6-desaturase activity and its mRNA in rats. Biosci. Biotechnol. Biochem. 67(6), 1258-1266 (2003).