A potent, selective inhibitor of FLAP
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Alternative(s)
10133MK-886 (sodium salt)
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MK-886

Item No. 21753

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid
CAS Number
118414-82-7
Synonyms
  • L-663,536
Molecular Formula
C27H34ClNO2S
Formula Weight
472.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 5 mg/mlEthanol: 0.14 mg/ml
λmax
225, 288 nm
SMILES
OC(C(C)(C)CC1=C(SC(C)(C)C)C(C=C(C(C)C)C=C2)=C2N1CC3=CC=C(Cl)C=C3)=O
InChi Code
InChI=1S/C27H34ClNO2S/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18/h8-14,17H,15-16H2,1-7H3,(H,30,31)
InChi Key
QAOAOVKBIIKRNL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    MK-886 is a potent, selective inhibitor of 5-lipoxygenase-activating protein (FLAP) that prevents 5-lipoxygenase activation in vivo and inhibits leukotriene biosynthesis in leukocytes with an IC50 of 2.5 nM.1 In human whole blood, leukotriene biosynthesis is inhibited by MK-886 with an IC50 of 1.1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dixon, R.A.F., Diehl, R.E., Opas, E., et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343, 282-284 (1990).

    Product Citations

    da Cunha, A.A., Silveira, J.S., Antunes, G.L., et al. Cysteinyl leukotriene induces eosinophil extracellular trap formation via cysteinyl leukotriene 1 receptor in a murine model of asthma. Exp. Lung Res. 47(8), 355-367 (2021).

    Van Anh, T.T., Mostafa, A., Rao, Z., et al. From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution. Acta Pharm. Sin. B. 11(6), 1629-1647 (2021).

    Change, Y.-C., Chen, Y.-J., Huang, C.-W., et al. Cyclic stretch facilitates myogenesis in C2C12 myoblasts and rescues thiazolidinedione-inhibited myotube formation. Front. Bioeng. Biotechnol. 4(27), (2016).

    Hsu, W.-H., Chen, T.-H., Lee, B.-H., et al. Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. Food Chem. Toxicol. 64, 94-103 (2014).

    Hsu, W.-H., Liao, T.-H., Lee, B.-H., et al. Ankaflavin regulates adipocyte function and attenuates hyperglycemia caused by high-fat diet via PPAR-γ activation. J. Funct. Foods 5(1), (2012).