An inhibitor of bacterial cell division
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

UCM53

Item No. 21768

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
naphthalene-1,3-diyl bis(3-chloro-4-hydroxybenzoate)
CAS Number
2468847-23-4
Molecular Formula
C24H14Cl2O6
Formula Weight
469.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
266 nm
SMILES
ClC1=C(O)C=CC(C(OC2=CC(C=CC=C3)=C3C(OC(C4=CC(Cl)=C(O)C=C4)=O)=C2)=O)=C1
InChi Code
InChI=1S/C24H14Cl2O6/c25-18-10-14(5-7-20(18)27)23(29)31-16-9-13-3-1-2-4-17(13)22(12-16)32-24(30)15-6-8-21(28)19(26)11-15/h1-12,27-28H
InChi Key
GWBTWBNCPASUNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $41

    Add

    1 mg

    $75

    Add

    5 mg

    $351

    Add

    10 mg

    $622

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    UCM53 is an inhibitor of bacterial cell division.1 It binds to the GTP site of the cell division protein FtsZ from B. subtilis in a fluorescent anisotropy assay. In B. subtilis, UCM53 (3 μM) reduces the number of FtsZ rings and increases the number of foci, as well as induces filamentation when used at a concentration of 12 μM. It is active against laboratory strains and clinical isolates of the Gram-positive bacteria B. subtilis, S. aureus, E. faecium, and E. faecalis (MICs = 2-8 mg/L) but is less effective against S. pneumoniae and the Gram-negative bacteria P. aeruginosa, E. coli, and K. pneumoniae (MICs = 32-128 mg/L). UCM53 inhibits cell growth in a panel of cancerous (IC50s = 16.9-76.5 mg/L) and non-cancerous mammalian cell lines (IC50s = 23.5-93.9 mg/L).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ruiz-Avila, L.B., Huecas, S., Artola, M., et al. Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ. ACS Chem. Biol. 8(9), 2072-2083 (2013).