An activator of the RLR pathway
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KIN1408

Item No. 21790

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[[4-(difluoromethoxy)phenyl][(5-methoxy-2-benzothiazolyl)amino]methyl]-8-quinolinol
CAS Number
1903800-11-2
Molecular Formula
C25H19F2N3O3S
Formula Weight
479.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
λmax
247, 302, 309 nm
SMILES
FC(F)OC1=CC=C(C(C2=C(O)C(N=CC=C3)=C3C=C2)N(C4=NC(C=C(OC)C=C5)=C5S4)[H])C=C1
InChi Code
InChI=1S/C25H19F2N3O3S/c1-32-17-9-11-20-19(13-17)29-25(34-20)30-21(15-4-7-16(8-5-15)33-24(26)27)18-10-6-14-3-2-12-28-22(14)23(18)31/h2-13,21,24,31H,1H3,(H,29,30)
InChi Key
YSGBFDHVEQJPPX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $194

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    Cayman Chemical
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    Product Description

    KIN1408 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity.1 It induces interferon regulatory factor 3 (IRF3) activation and translocation into the nucleus in a concentration-dependent manner in HEK293 cells without inducing cellular toxicity. KIN1408 induces expression of the innate immune genes MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate (PMA; Item No. 10008014). It exhibits concentration-dependent broad-spectrum antiviral activity against dengue virus 2 as well as the influenza A, Ebola, Nipah, and Lassa viruses.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pattabhi, S., Wilkins, C.R., Dong, R., et al. Targeting innate immunity for antiviral therapy through small molecule agonists of the RLR pathway. J. Virol. 90(5), 2372-2387 (2015).