A selective β2-AR agonist
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Olodaterol

Item No. 21794

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one
CAS Number
868049-49-4
Synonyms
  • BI-1744
Molecular Formula
C21H26N2O5
Formula Weight
386.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 15 mg/mlEthanol: 1 mg/ml
λmax
220, 303 nm
SMILES
COC1=CC=C(CC(C)(C)N([H])C[C@H](O)C2=C(OCC(N3[H])=O)C3=CC(O)=C2)C=C1
InChi Code
InChI=1S/C21H26N2O5/c1-21(2,10-13-4-6-15(27-3)7-5-13)22-11-18(25)16-8-14(24)9-17-20(16)28-12-19(26)23-17/h4-9,18,22,24-25H,10-12H2,1-3H3,(H,23,26)/t18-/m0/s1
InChi Key
COUYJEVMBVSIHV-SFHVURJKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $98

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    5 mg

    $318

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    10 mg

    $539

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    25 mg

    $1,225

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    Product Description

    Olodaterol is a selective agonist of β2-adrenergic receptors (β2-ARs; EC50s = 97.7 and 2,725 nM for human β2- and β1-ARs, respectively).1 In vivo, olodaterol completely reverses acetylcholine-induced bronchoconstriction without cardiovascular side effects in guinea pigs. It also exhibits dose-dependent bronchoprotection in a beagle model of acetylcholine-induced bronchoconstriction for a period of 24 hours, indicating potential for once-daily dosing.2 Formulations containing olodaterol have been used to treat bronchoconstriction associated with chronic obstructive pulmonary disease.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boujyssou, T., Hoenke, C., Rudolf, K., et al. Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24 h bronchodilatory efficacy. Bioorg. Med. Chem. Lett. 20(4), 1410-1414 (2010).

    2. Boyssou, T., Casarosa, P., Naline, E., et al. Pharmacological characterization of olodaterol, a novel inhaled β2-adrenoceptor agonist exerting a 24-hour-long duration of action in preclinical models. J. Pharmacol. Exp. Ther. 334(1), 53-62 (2010).

    3. Donohue, J.F. Systematic review comparing LABA, olodaterol, and indacaterol: Limitations. Int. J. Chron. Obstruct. Pulmon. Dis. 9, 1331-1333 (2014).