A fungal metabolite with antiallergenic, anti-angiogenic, and antiviral activity
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Sulochrin

Item No. 21797

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxy-benzoic acid, methyl ester
CAS Number
519-57-3
Molecular Formula
C17H16O7
Formula Weight
332.3
Purity
≥99%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O=C(C1=C(OC)C=C(O)C=C1C(OC)=O)C2=C(O)C=C(C)C=C2O
InChi Code
InChI=1S/C17H16O7/c1-8-4-11(19)15(12(20)5-8)16(21)14-10(17(22)24-3)6-9(18)7-13(14)23-2/h4-7,18-20H,1-3H3
InChi Key
YJRLSCDUYLRBIZ-UHFFFAOYSA-N
Origin
Fungus/Aspergillus terreus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $214

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    5 mg

    $797

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    Cayman Chemical
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    Product Description

    Sulochrin is a fungal metabolite produced by A. terreus and Penicillium that exhibits antiallergenic, anti-angiogenic, and antiviral activities. Sulochrin inhibits eosinophil degranulation.1 It prevents leukotriene C4 (LTC4) release, O2- production, and IL-8 production (IC50s = 0.03, 8.2, 9.6, and 8.7 μM, respectively) and inhibits migration of human and guinea pig eosinophils (IC50 = 0.2-0.4 μM). Sulochrin inhibits VEGF-induced capillary tube formation of human umbilical vein endothelial cells (HUVEC) in vitro (70% inhibition at 10 mg/ml).2 It also inhibits hepatitis C viral infection (IC50 = 24.4 μM) in vitro.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohashi, H., Motegi, Y., Kita, H., et al. Sulochrin inhibits eosinophil activation and chemotaxis. Inflamm. Res. 47(10), 409-415 (1998).

    2. Lee, H.J., Lee, J.H., Hwang, B.Y., et al. Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs. J. Antibiot. (Tokyo) 55(6), 552-556 (2002).

    3. Nakajima, S., Watashi, K., Kamisuki, S., et al. Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives. Biochem. Biophys. Res. Commun. 440(4), 515-520 (2013).