A small molecule for hepatocyte expansion
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Stem Cell Research
Reprogramming

BRD6125

Item No. 21804

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(5-chloro-2-methylphenyl)(methylsulfonyl)amino]-N-(2,6-difluorophenyl)-acetamide
CAS Number
708219-39-0
Synonyms
  • FPH1
Molecular Formula
C16H15ClF2N2O3S
Formula Weight
388.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/ml
λmax
261 nm
SMILES
CC1=C(N(CC(NC2=C(F)C=CC=C2F)=O)S(C)(=O)=O)C=C(Cl)C=C1
InChi Code
InChI=1S/C16H15ClF2N2O3S/c1-10-6-7-11(17)8-14(10)21(25(2,23)24)9-15(22)20-16-12(18)4-3-5-13(16)19/h3-8H,9H2,1-2H3,(H,20,22)
InChi Key
WAOBCCBUTHNTFO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

    $106

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    10 mg

    $158

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    25 mg

    $354

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    Product Description

    BRD6125, also known as functional proliferation hits 1 (FPH1), is a small molecule that increases the number and activity of hepatocytes in vitro.1 It dramatically increases expansion of primary human hepatocytes and induces maturation of hepatocyte-like cells (iHeps). It also induces maturation in two pluripotent cell lines. This product is also available as part of Cayman's Hepatocyte Differentiation Reagent Kit (Item No. 44737).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shan, J., Schwartz, R.E., Ross, N.T., et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat. Chem. Biol. 9(8), 514-520 (2013).