An inhibitor of NF-κB
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SC-75741

Item No. 21818

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(6-benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide
CAS Number
913822-46-5
Molecular Formula
C29H23N7O2S2
Formula Weight
565.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.2 mg/mlDMSO: 0.5 mg/mlDMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml
λmax
206, 256, 313 nm
SMILES
O=C(NC1=NC(C=CC(C(C2=CC=CC=C2)=O)=C3)=C3N1)C4=CSC(C5CCN(C6=C7C(C=CS7)=NC=N6)CC5)=N4
InChi Code
InChI=1S/C29H23N7O2S2/c37-24(17-4-2-1-3-5-17)19-6-7-20-22(14-19)34-29(33-20)35-27(38)23-15-40-28(32-23)18-8-11-36(12-9-18)26-25-21(10-13-39-25)30-16-31-26/h1-7,10,13-16,18H,8-9,11-12H2,(H2,33,34,35,38)
InChi Key
QNZVBFMXWNWVKG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    SC-75741 is an inhibitor of NF-κB (EC50 = 0.2 μM in an NF-κB reporter gene assay).1 It inhibits replication of human, avian, and swine influenza virus strains in MDCK cells in a concentration-dependent manner.2 It also reversibly inhibits replication of H5N1 and H7N7 avian influenza virus strains in human A549 cells. In vivo, SC-75741 (15 mg/kg, i.p.) reduces viral mRNA and production of IL-6 and CXCL10/IP-10 in the lungs of H5N1 infected mice. SC-75741 is also protective against H5N1 and H7N7 infection in mice when administered for 7 days prior to or up to 4 days post infection.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leban, J., Baierl, M., Mies, J., et al. A novel class of potent NF-κB signaling inhibitors. Bioorg. Med. Chem. Lett. 17(21), 5858-5862 (2007).

    2. Ehrhardt, C., Rückle, A., Hrincius, E.R., et al. The NF-κB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance. Cell. Microbiol. 15(7), 1198-1211 (2013).

    3. Haasbach, E., Reiling, S.J., Ehrhardt, C., et al. The NF-κB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus. Antiviral Res. 99(3), 336-344 (2013).