A potent activator of SUR2-Kir6 and KATP channels
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P1075

Item No. 21849

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl-guanidine
CAS Number
60559-98-0
Molecular Formula
C12H17N5
Formula Weight
231.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: <100mMEthanol: <50mM
λmax
239 nm
SMILES
CCC(C)(C)/N=C(NC#N)/NC1=CC=CN=C1
InChi Code
InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)
InChi Key
HKZNADVVGXKQDL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

    $197

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    Product Description

    P1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-Kir6) with an EC50 value of 45 nM for SUR2B-Kir6 channel activation.1 It is highly selective for SUR2 over SUR1 isoforms (IC50s = 9-46 nM and 1.02 mM, respectively, in a radioligand binding assay). P1075 increases outflow facility, a marker of reduced intraocular pressure, in human eye anterior segments ex vivo.2 It also reduces infarct size in isolated rabbit hearts via activation of mitochondrial ATP-sensitive potassium channels (KATP; EC50s = 60-90 nM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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