A selective inhibitor of MMP-8
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MMP-8 Inhibitor I

Item No. 21852

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R)-1,2,3,4-tetrahydro-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-3-isoquinolinecarboxamide
CAS Number
236403-25-1
Synonyms
  • Matrix Metalloproteinase-8 Inhibitor I
Molecular Formula
C17H18N2O5S
Formula Weight
362.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 200 mg/ml
SMILES
O=C(NO)[C@@H]1N(S(C2=CC=C(OC)C=C2)(=O)=O)CC3=CC=CC=C3C1
InChi Code
InChI=1S/C17H18N2O5S/c1-24-14-6-8-15(9-7-14)25(22,23)19-11-13-5-3-2-4-12(13)10-16(19)17(20)18-21/h2-9,16,21H,10-11H2,1H3,(H,18,20)/t16-/m1/s1
InChi Key
PPELJLBDXLMTEW-MRXNPFEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $222

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    Product Description

    MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM.1 This inhibitor does not target the activities of other MMPs in vitro.2,3 MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization.4 Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matter, H., Schudok, M., Schwab, W., et al. Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors: Design, synthesis and structure-activity relationship. Bioorg. Med. Chem. 10(11), 3529-3544 (2002).

    2. McNulty, A.L., Weinberg, J.B., and Guilak, F. Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus. Clin. Orthop. Relat. Res. 467(6), 1557-1567 (2009).

    3. Prager, G.W., Breuss, J.M., Steurer, S., et al. Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells. Blood 103(3), 955-962 (2004).

    4. Chen, Q., Jin, M., Yang, F., et al. Matrix metalloproteinases: Inflammatory regulators of cell behaviors in vascular formation and remodeling. Mediators Inflamm. 928315 (2013).

    5. Decock, J., Hendricks, W., Thirkettle, S., et al. Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice. Breast Cancer Res. 17(1), 38 (2015).

    6. Sarper, M., Allen, M.D., Gomm, J., et al. Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function. Breast Cancer Res. 19(1), 33 (2017).