An active cholesterol metabolite
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3β-hydroxy-5-Cholestenoic Acid

Item No. 21859

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-3-hydroxy-cholest-5-en-26-oic acid
CAS Number
6561-58-6
Synonyms
  • 3β-hydroxy-5-CA
  • Cholesterol-26-carboxylic Acid
Molecular Formula
C27H44O3
Formula Weight
416.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
[H][C@]12[C@@]([C@@](CC[C@]3([H])[C@H](C)CCCC(C)C(O)=O)([H])[C@]3(C)CC2)([H])CC=C4C[C@@H](O)CC[C@@]41C
InChi Code
InChI=1S/C27H44O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h8,17-18,20-24,28H,5-7,9-16H2,1-4H3,(H,29,30)/t17-,18?,20+,21+,22-,23+,24+,26+,27-/m1/s1
InChi Key
WVXOMPRLWLXFAP-AMQKJUDNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $202

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    1 mg

    $380

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    Product Description

    3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1.1 3β-hydroxy-5-Cholestenoic acid is a modulator of γ-secretase that decreases amyloid β (1-42) peptide (Aβ42; EC50 = 250 nM) and increases Aβ38 levels with no effect on total Aβ in CHO2B7 cells. It decreases endogenous murine Aβ42 production by 60 and 75% in mouse postnatal neuron-glia cultures at concentrations of 3 and 10 μM, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jung, J.I., Price, A.R., Ladd, T.B., et al. Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. Mol. Neurodegener. 10(29), (2015).