A DNA methyltransferase 1 inhibitor
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SW155246

Item No. 21865

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide
CAS Number
420092-79-1
Molecular Formula
C16H11ClN2O5S
Formula Weight
378.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.16 mg/ml
λmax
212, 304 nm
SMILES
ClC1=CC=C(S(NC2=CC=C(O)C3=C2C=CC=C3)(=O)=O)C=C1[N+]([O-])=O
InChi Code
InChI=1S/C16H11ClN2O5S/c17-13-6-5-10(9-15(13)19(21)22)25(23,24)18-14-7-8-16(20)12-4-2-1-3-11(12)14/h1-9,18,20H
InChi Key
JDYDEJYIVZNWQU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $43

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    10 mg

    $190

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    25 mg

    $416

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    Cayman Chemical
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    Product Description

    SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1; IC50 = 1.2 μM).1 It is selective for human DNMT1 over murine DNMT3 (IC50 = 38 μM). SW155246 inhibits HeLa and A549 tumor cell growth in a redox-independent manner (IC50s = 8-20 μM). It also inhibits genomic methylation in HeLa cells when used at concentrations ranging from 10 to 18.6 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kilgore, J.A., Du, X., Melito, L., et al. Identification of DNMT1 selective antagonists using a novel scintillation proximity assay. The Journal of Biological Chemisty 288(27), 19673-19684 (2013).