A selective inhibitor of ALDH1A1
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Product Categories

Product Type

Small Molecule Modulators
Small Molecule Inhibitors

Research Area

CM037

Item No. 21868

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrrolidinyl)propyl][1]benzothieno[3,2-d]pyrimidin-2-yl]thio]-acetic acid, ethyl ester
CAS Number
896795-60-1
Molecular Formula
C21H25N3O3S2
Formula Weight
431.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2); (1:7): 0.125 mg/mlDMSO: 2.5 mg/ml
λmax
254, 334, 348 nm
SMILES
O=C1N(CCCN2CCCC2)C(SCC(OCC)=O)=NC3=C1SC4=C3C=CC=C4
InChi Code
InChI=1S/C21H25N3O3S2/c1-2-27-17(25)14-28-21-22-18-15-8-3-4-9-16(15)29-19(18)20(26)24(21)13-7-12-23-10-5-6-11-23/h3-4,8-9H,2,5-7,10-14H2,1H3
InChi Key
SKDRHRAYBYQVNU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    CM037 is a selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1; IC50 = 4.6 µM).1 It is selective for ALDH1A1 over eight other ALDH isoenzymes at a concentration of 20 µM. CM037 is a competitive inhibitor against acetaldehyde with a Ki value of 0.23 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morgan, C.A., and Hurley, T.D. Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. J. Med. Chem. 58(4), 1964-1975 (2015).