An inhibitor of Wnt signaling
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Signaling
Wnt Signaling

G244-LM

Item No. 21876

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5,7,8-tetrahydro-2-[4-[2-(methylsulfonyl)phenyl]-1-piperazinyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
CAS Number
1563007-08-8
Molecular Formula
C18H22N4O3S2
Formula Weight
406.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 0.25 mg/ml
λmax
213, 235, 300 nm
SMILES
O=C(N=C(N1CCN(C2=C(S(C)(=O)=O)C=CC=C2)CC1)N3)C4=C3CCSC4
InChi Code
InChI=1S/C18H22N4O3S2/c1-27(24,25)16-5-3-2-4-15(16)21-7-9-22(10-8-21)18-19-14-6-11-26-12-13(14)17(23)20-18/h2-5H,6-12H2,1H3,(H,19,20,23)
InChi Key
JSQPAEVPPSCQMV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    G244-LM is an inhibitor of Wnt signaling.1 It inhibits Wnt3a-induced signaling in HEK293 human and 10T1/2 mouse cells in a reporter assay. It also inhibits Wnt signaling and colony formation in COLO-320DM and SW403, but not HCT-15 or DLD-1, colorectal cancer cells when used at a concentration of 0.2 µM for seven to 13 days. G244-LM inhibits growth of mouse intestinal organoids (IC50 = 0.11 µM) and organoid spheroids cultured from small intestine adenomas isolated from ApcMin mice, which exhibit constitutively activated Wnt/β-catenin signaling.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lau, T., Chan, E., Callow, M., et al. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Res. 73(10), 3132-3144 (2013).