An inhibitor of the presynaptic choline transporter
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ML-352

Item No. 21878

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]-benzamide
CAS Number
1649450-12-3
Molecular Formula
C21H29N3O4
Formula Weight
387.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 5 mg/ml
λmax
212, 257 nm
SMILES
CN1CCC(OC2=C(OC)C=CC(C(NCC3=CC(C(C)C)=NO3)=O)=C2)CC1
InChi Code
InChI=1S/C21H29N3O4/c1-14(2)18-12-17(28-23-18)13-22-21(25)15-5-6-19(26-4)20(11-15)27-16-7-9-24(3)10-8-16/h5-6,11-12,14,16H,7-10,13H2,1-4H3,(H,22,25)
InChi Key
WBLVOWHFRUAMCP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $108

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    10 mg

    $196

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    Product Description

    ML-352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with Ki values of 92 and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively.1 It is selective for CHT over dopamine, norepinephrine, and serotonin transporters in HEK293 cells expressing human transporters when used at a concentration of 5 μM as well as a panel of 68 G protein-coupled receptors, ion channels, and transporters when used at a concentration of 10 μM. ML-352 (5 μM) increases cell surface expression of CHT without affecting total protein levels.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ennis, E.A., Wright, J., Retzlaff, C.L., et al. Identification and characterization of ML352: A novel, noncompetitive inhibitor of the presynaptic choline transporter. ACS Chem. Neurosci. 6(3), 417-427 (2015).