A benzimidazole agent with anthelmintic and antiparasitic effects
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Ricobendazole

Item No. 21880

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[6-(propylsulfinyl)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester
CAS Number
54029-12-8
Synonyms
  • Albendazole sulfoxide
Molecular Formula
C12H15N3O3S
Formula Weight
281.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
λmax
224, 294 nm
SMILES
O=C(OC)NC1=NC2=CC=C(S(CCC)=O)C=C2N1
InChi Code
InChI=1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
InChi Key
VXTGHWHFYNYFFV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $49

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    10 g

    $86

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    25 g

    $154

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    50 g

    $283

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    Cayman Chemical
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    Product Description

    Ricobendazole, also known as albendazole sulfate, is a benzimidazole agent that inhibits tubulin polymerization and is commonly used as an anthelmintic and antiparasitic agent, with IC90 values ranging from 3.8 x 10-2 to <10-4 µg/ml against Encephalitozoon species.1,2,3,4 In vitro, ricobendazole effectively kills Taenia cysts, with EC50 and EC99 values of 0.068 and 0.556 µg/ml, respectively, in 11-day cultures, and inhibits adherence in Giardia species with a 24-hour IC50 value of 3.15 µM.5,6 This agent is metabolized from albendazole via cytochrome P450 (CYP450) and may modulate CYP450 activity.1,2,7 In rat microsomes, ricobendazole reduces the activity of ethoxyresorufin O-deethylase (EROD) by more than 5-fold relative to albendazole, with an IC50 value of 5 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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