An OGT inhibitor
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OSMI-1

Item No. 21894

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αR-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-benzeneacetamide
CAS Number
1681056-61-0
Molecular Formula
C28H25N3O6S2
Formula Weight
563.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mLDMF:PBS (pH 7.2) (1:5): 0.16 mg/mLDMSO: 20 mg/mL
λmax
245, 327 nm
SMILES
O=C([C@@H](C1=CC=CC=C1OC)NS(C2=CC(C=CC(N3)=O)=C3C=C2)(=O)=O)N(CC4=CC=CO4)CC5=CC=CS5
InChi Code
InChI=1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)/t27-/m1/s1
InChi Key
IYIGLWQQAMROOF-HHHXNRCGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $160

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    10 mg

    $288

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    25 mg

    $629

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    Product Description

    OSMI-1 is a quinolinone-6-sulfonamide that inhibits O-GlcNAc transferase (OGT; IC50 = 2.7 μM) in vitro.1 It is cell permeable and inhibits global O-GlcNAcylation in a dose-dependent manner in CHO cells. OSMI-1 induces a mass shift of nucleoporin62 (Nup62) that corresponds to the loss of O-GlcNAc residues and decreases levels of cellular O-GlcNAcase (OGA). OSMI-1 (50 μM) also causes a 50% decrease in CHO cell viability after 24 hours.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ortiz-Meoz, R.F., Jiang, J., Lazarus, M.B., et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 10(6), 1392-1397 (2015).