A Piezo1 channel agonist
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Yoda1

Item No. 21904

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine
CAS Number
448947-81-7
Molecular Formula
C13H8Cl2N4S2
Formula Weight
355.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 2.5 mg/ml
λmax
314 nm
SMILES
ClC(C=CC=C1Cl)=C1CSC2=NN=C(C3=CN=CC=N3)S2
InChi Code
InChI=1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2
InChi Key
BQNXBSYSQXSXPT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $106

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    10 mg

    $174

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    25 mg

    $337

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    Product Description

    Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively).1 It is selective for Piezo1 as it elicits Ca2+ flux in Piezo1- but not Piezo2-transfected HEK293T cells. Yoda1 slows the inactivation phase of murine Piezo1 transient currents and sensitizes them to activation by mechanical pressure, reducing the half maximal activation pressure by 15 mm Hg in an artificial droplet lipid bilayer. Treatment of wild-type red blood cells, but not Piezo1 knockout cells, with 15 μM yoda1 leads to dehydration and a change in cell shape resulting in progression from discocytes to echinocytes to spherocytes.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Syeda, R., Xu, J., Dubin, A.E., et al. Chemical activation of the mechanotransduction channel Piezo1. Elife 4, e07369 (2015).

    2. Cahalan, S.M., Lukacs, V., Ranade, S.S., et al. Piezo1 links mechanical forces to red blood cell volume. Elife 4, e07370 (2015).