A selective inhibitor of ANO1 A selective inhibitor of ANO1 A selective inhibitor of ANO1
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MONNA

Item No. 21917

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
CAS Number
1572936-83-4
Molecular Formula
C18H14N2O5
Formula Weight
338.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: slightly soluble
λmax
214, 264, 295, 376 nm
SMILES
COC1=CC(NC2=C(C(O)=O)C=C([N+]([O-])=O)C=C2)=CC3=CC=CC=C31
InChi Code
InChI=1S/C18H14N2O5/c1-25-17-9-12(8-11-4-2-3-5-14(11)17)19-16-7-6-13(20(23)24)10-15(16)18(21)22/h2-10,19H,1H3,(H,21,22)
InChi Key
JIVRLHBAUUZTNC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $186

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    25 mg

    $420

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    Product Description

    MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 µM in Xenopus oocytes), a calcium-activated chloride channel (CaCC).1 It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 µM. MONNA (10 µM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride.2 It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oh, S.J., Hwang, S.J., Jung, J.E., et al. MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol. Pharmacol. 84(5), 726-735 (2013).

    2. Boedtkjer, D.M.B., Kim, S., Jensen, A.B., et al. New selective inhibitors of calcium-activated chloride channels - T16Ainh-A01, CaCCinh-A01 and MONNA - what do they inhibit? Br. J. Pharmacol. 172(16), 4158-4172 (2015).