A neuroprotective agent
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OBA-09

Item No. 21918

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(1,2-dioxopropoxy)-benzoic acid
CAS Number
856095-68-6
Molecular Formula
C10H8O5
Formula Weight
208.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30mg/mLDMSO: 40mg/mLEthanol: 80mg/mLPBS (pH 7.2): 2.7mg/mL
λmax
238, 300 nm
SMILES
O=C(O)C1=C(OC(C(C)=O)=O)C=CC=C1
InChi Code
InChI=1S/C10H8O5/c1-6(11)10(14)15-8-5-3-2-4-7(8)9(12)13/h2-5H,1H3,(H,12,13)
InChi Key
ULWCDKMLERRCJA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $32

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    5 mg

    $110

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    10 mg

    $142

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    25 mg

    $315

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    Product Description

    OBA-09 is an ester of pyruvate and salicylic acid that has neuroprotective properties.1 It decreases lactate dehydrogenase (LDH) release and prevents cell death induced by NMDA or zinc, and reduces the production of reactive oxygen species (ROS) induced by oxygen-glucose deprivation in mixed rat primary cortical cells when used at concentrations of 10 and 15 mM. OBA-09 (10 mg/kg) reduces infarct volume by 89.9% and decreases expression of IL-1β, inducible nitric oxide synthase (iNOS), COX-2, and TNF-α in the brain in a rat model of ischemia induced by middle cerebral artery occlusion (MCAO).1,2 It improves motor performance in the rotarod test in the same model when administered at a dose of 10 mg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, S.W., Kim, H.J., Shin, J.H., et al. Robust protective effects of a novel multimodal neuroprotectant oxopropanoyloxy benzoic acid (a salicylic acid/pyruvate ester) in the postischemic brain. Mol. Pharmacol. 79(2), 220-228 (2011).

    2. Lee, H.-K., Kim, S.-W., Jin, Y., et al. Anti-inflammatory effects of OBA-09, a salicylic acid/pyruvate ester, in the postischemic brain. Brain Res. 1528, 68-79 (2013).