An inhibitor of PRMT1
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CID-2818500

Item No. 21919

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1'-(1-nitro-1,2-ethenediyl)bis-benzene
CAS Number
1215-07-2
Synonyms
  • α-Nitrostilbene
  • NSC 385
Molecular Formula
C14H11NO2
Formula Weight
225.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 20 mg/mlEthanol: 12 mg/ml
λmax
228, 316 nm
SMILES
O=[N+](/C(C1=CC=CC=C1)=C/C2=CC=CC=C2)[O-]
InChi Code
InChI=1S/C14H11NO2/c16-15(17)14(13-9-5-2-6-10-13)11-12-7-3-1-4-8-12/h1-11H/b14-11+
InChi Key
QIFBVYLHLLTNLI-SDNWHVSQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $63

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    100 mg

    $119

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    Product Description

    CID-2818500 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 11 μM in a histone H4 methylation assay).1 It also inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, when used at concentrations of 10 and 100 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dillon, M.B., Bachovchin, D.A., Brown, S.J., et al. Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization. ACS Chem. Biol. 7(7), 1198-1204 (2012).