An inhibitor of PCNA
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T2AA (hydrochloride)

Item No. 21921

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
βS-amino-4-(4-hydroxyphenoxy)-3,5-diiodo-benzenepropanol, monohydrochloride
CAS Number
2138331-07-2
Synonyms
  • T2-amino Alcohol
Molecular Formula
C15H15I2NO3 • HCl
Formula Weight
547.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:8): 0.11
λmax
229 nm
SMILES
OC(C=C1)=CC=C1OC2=C(I)C=C(C[C@H](N)CO)C=C2I.Cl
InChi Code
InChI=1S/C15H15I2NO3.ClH/c16-13-6-9(5-10(18)8-19)7-14(17)15(13)21-12-3-1-11(20)2-4-12;/h1-4,6-7,10,19-20H,5,8,18H2;1H/t10-;/m0./s1
InChi Key
ILDRWUYIAXQKLH-PPHPATTJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    T2AA is an inhibitor of proliferating cell nuclear antigen (PCNA).1 It inhibits protein-protein interactions between PCNA and a PIP-box-containing peptide (IC50 = 1 μM) and full-length p21 as well as reduces cellular colocalization of PCNA and DNA polymerase δ. T2AA inhibits DNA replication and cell growth in U2OS and HeLa cells in a concentration-dependent manner and induces cell cycle arrest at the S phase when used at a concentration of 20 μM. It also increases DNA double strand break formation induced by cisplatin (Item No. 13119) in a neutral comet assay and cisplatin-induced inhibition of clonogenic survival in HeLa and U2OS cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Punchihewa, C., Inoue, A., Hishiki, A., et al. Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. The Journal of Biological Chemisty 287(17), 14289-14300 (2012).

    2. Inoue, A., Kikuchi, S., Hishiki, A., et al. A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. The Journal of Biological Chemisty 289(10), 7109-7120 (2014).