A non-selective inhibitor of CaCCs
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

CaCC(inh)-A01

Item No. 21922

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid
CAS Number
407587-33-1
Synonyms
  • TMEM16 Blocker I
Molecular Formula
C18H21NO4S
Formula Weight
347.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
λmax
228, 258, 343 nm
SMILES
CC(C)(C)C1CCC(C(C(O)=O)=C(NC(C2=CC=CO2)=O)S3)=C3C1
InChi Code
InChI=1S/C18H21NO4S/c1-18(2,3)10-6-7-11-13(9-10)24-16(14(11)17(21)22)19-15(20)12-5-4-8-23-12/h4-5,8,10H,6-7,9H2,1-3H3,(H,19,20)(H,21,22)
InChi Key
ACLUEOBQFRYTQS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $74

    Add

    10 mg

    $141

    Add

    25 mg

    $327

    Add

    50 mg

    $543

    Add
    Product Description

    CaCC(inh)-A01 is a non-selective inhibitor of calcium-activated chloride channels (CaCCs) that blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelium (mean IC50 = 10 µM).1 CaCC(inh)-A01 (30 µM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride.2 CaCC(inh)-A01 also attenuates CaCC TMEM16-A-induced proliferation in cancer cell lines through targeted degradation of the protein and reduces the activity of large-conductance calcium-activated potassium channels (KCa1.1/BK) in human red blood cells.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. De La Fuente, R., Namkung, W., Mills, A., et al. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol. Pharmacol. 73(3), 758-768 (2008).

    2. Boedtkjer, D.M.B., Kim, S., Jensen, A.B., et al. New selective inhibitors of calcium-activated chloride channels - T16Ainh-A01, CaCCinh-A01 and MONNA - what do they inhibit? Br. J. Pharmacol. 172(16), 4158-4172 (2015).

    3. Bill, A., Hall, M.L., Borawski, J., et al. Small molecule-facilitated degradation of ANO1 protein: A new targeting approach for anticancer therapeutics. The Journal of Biological Chemisty 289(16), 11029-11041 (2014).

    4. Kucherenko, Y.V., Wagner-Britz, L., Bernhardt, I., et al. Effect of chloride channel inhibitors on cytosolic Ca2+ Levels and Ca2+-activated K+ (Gardos) channel activity in human red blood cells. J. Membr. Biol. 246(4), 315-326 (2013).