A macrolide antibiotic
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Lexithromycin

Item No. 22002

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
erythromycin, 9-(O-methyloxime)
CAS Number
53066-26-5
Molecular Formula
C38H70N2O13
Formula Weight
763.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mM
SMILES
C[C@H]1[C@H](O)[C@@](OC)(C)C[C@@](O[C@H]([C@@H](C)C(O[C@H](CC)[C@]([C@H](O)[C@H]/2C)(O)C)=O)[C@H](C)[C@@H](O[C@@]3([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@](C)(O)C[C@@H](C)C2=N/OC)([H])O1
InChi Code
InChI=1S/C38H70N2O13/c1-15-26-38(10,46)31(42)21(4)28(39-48-14)19(2)17-36(8,45)33(53-35-29(41)25(40(11)12)16-20(3)49-35)22(5)30(23(6)34(44)51-26)52-27-18-37(9,47-13)32(43)24(7)50-27/h19-27,29-33,35,41-43,45-46H,15-18H2,1-14H3/b39-28+/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
InChi Key
HPZGUSZNXKOMCQ-SQYJNGITSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Lexithromycin is a semisynthetic antibiotic derived from erythromycin (Item No. 16486).1 Lexithromycin has improved absorption in vivo over erythromycin due to increased hydrophopicity and pH stability.1 As with other macrolides, lexithromycin prevents protein synthesis by binding the ribosome at the polypeptide exit tunnel.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hunt, E., Knowles, D.J., Shillingford, C., et al. Erythromycin A 11,12-methylene acetal. J. Antibiot. (Tokyo) 41(11), 1644-1648 (1988).

    2. Wilson, D.N. The A-Z of bacterial translation inhibitors. Crit. Rev. Biochem. Mol. Biol. 44(6), 393-433 (2009).