An Analytical Reference Standard
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Certified Reference Material(s)
42588Buspirone (hydrochloride) (CRM)
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Buspirone (hydrochloride)

Item No. 22028

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • MJ9022-1
Technical Information
Formal Name
8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione, monohydrochloride
CAS Number
33386-08-2
Molecular Formula
C21H31N5O2 • HCl
Formula Weight
422.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
237, 299 nm
SMILES
O=C1CC2(CCCC2)CC(N1CCCCN(CC3)CCN3C4=NC=CC=N4)=O.Cl
InChi Code
InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H
InChi Key
RICLFGYGYQXUFH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Buspirone (hydrochloride) (Item No. 22028) is an analytical reference standard that is categorized as an anxiolytic.1 It modulates serotonin and dopamine receptors, undergoes rapid first-pass metabolism, and is metabolized to phenylpiperazine (Item No. 11203), which has high affinity for α-adrenergic receptors.2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gale, C., and Oakley-Brown, M. Anxiety disorder. B.M.J. 321(7270), 1204-1207 (2000).

    2. Rënyi, L., Evenden, J.L., Fowler, C.J., et al. The pharmacological profile of (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a selective 5-hydroxytryptamine1A receptor agonist. J. Pharmacol. Exp. Ther. 299(3), 883-893 (2001).