A STAT3 inhibitor
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MM-206

Item No. 22032

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,4,5,6-pentafluoro-N-[4-hydroxy-3-(phenylthio)-1-naphthalenyl]-benzenesulfonamide
CAS Number
1809581-87-0
Molecular Formula
C22H12F5NO3S2
Formula Weight
497.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:8): 0.1 mg/mlDMSO: 10 mg/ml
λmax
222, 247 nm
SMILES
OC(C(C=CC=C1)=C1C(NS(C2=C(F)C(F)=C(F)C(F)=C2F)(=O)=O)=C3)=C3SC4=CC=CC=C4
InChi Code
InChI=1S/C22H12F5NO3S2/c23-16-17(24)19(26)22(20(27)18(16)25)33(30,31)28-14-10-15(32-11-6-2-1-3-7-11)21(29)13-9-5-4-8-12(13)14/h1-10,28-29H
InChi Key
ZXJHEANDHXHGMV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $94

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    10 mg

    $174

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    25 mg

    $412

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    Cayman Chemical
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    Product Description

    MM-206 is an inhibitor of STAT3 (IC50 = 1.16 µM in an SPR-based competitive assay).1 It inhibits STAT3 phosphorylation induced by granulocyte colony-stimulating factor (G-CSF) in HL-60, Kasumi-1, and MOLM-13 acute myeloid leukemia (AML) cells (IC50s = 0.8, 1.9, and 1.1 µM, respectively). MM-206 induces apoptosis more potently in AML cell lines and patient-derived primary AML tumor cells than in acute lymphoblastic leukemia cells, which do not have upregulated STAT3 activity. It also slows disease progression and improves survival in an AML mouse xenograft model when administered at a dose of 30 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Minus, M.B., Liu, W., Vohidov, F., et al. Rhodium(II) proximity-labeling identifies a novel target site on STAT3 for inhibitors with potent anti-leukemia activity. Angew. Chem. Int. Ed. Engl. 54(44), 13085-13089 (2015).