Pricing updated 2019-05-26. Prices are subject to change without notice.
Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells. It is subject to citrullination by peptidyl arginine deiminase 2 (PAD2; Item No. 10785) under high calcium concentrations, which can occur during macrophage apoptosis.1 Citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs).1,2 ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.2 Cayman's Citrullinated Vimentin Monoclonal Antibody (Clone 12G11) can be used for Western blot and ELISA applications. The antibody recognizes citrullinated vimentin at ~54 kDa from human samples.
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Asaga, H., Yamada, M., and Senshu, T. Selective deimination of vimentin in calcium ionophore-
Soós, L., Szekanecz, Z., Szabó, Z., et al. Clinical evaluation of anti-