Citrullinated Vimentin Monoclonal Antibody (Clone 12G11) | Cayman Chemical
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Citrullinated Vimentin Monoclonal Antibody (Clone 12G11)

Item № 22054
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SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     100 µg $329.00 0.00

Pricing updated 2018-11-16. Prices are subject to change without notice.

Description

Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells. It is subject to citrullination by peptidyl arginine deiminase 2 (PAD2; Item No. 10785) under high calcium concentrations, which can occur during macrophage apoptosis.1 Citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs).1,2 ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.2 Cayman's Citrullinated Vimentin Monoclonal Antibody (Clone 12G11) can be used for Western blot and ELISA applications. The antibody recognizes citrullinated vimentin at ~54 kDa from human samples.

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Technical Information
Immunogen
Citrullinated peptide sequence from an internal region of human vimentin
Clone Designation
12G11
Formulation
100 µg of protein G-purified IgG
Storage Buffer
PBS, pH 7.2 with 50% glycerol and 0.02% sodium azide
Host
Mouse
Isotype
IgG1
Applications
ELISA, and WB
Cross Reactivity
  • (+) Citrullinated vimentin
  • (-) Unmodified protein
Species Reactivity
  • (+) Human citrullinated vimentin
UniProt Accession №
P08670

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 1 year
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Asaga, H., Yamada, M., and Senshu, T. Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages Biochem. Bioph. Res. Commun. 243(3), 641-646 (1998).

2. Soós, L., Szekanecz, Z., Szabó, Z., et al. Clinical evaluation of anti-mutated citrullinated vimentin by ELISA in rheumatoid arthritis J. Rheumatol. 34(8), 1658-1663 (2007).

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