A DNA alkylating agent
Related Products
Isomer(s)
33852Arteannuin B
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Illudin M

Item No. 22062

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3'S,6'R)-2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one
CAS Number
1146-04-9
Synonyms
  • DR-15977
  • (-)-Illudin M
  • NSC 400978
  • NSC 626370
Molecular Formula
C15H20O3
Formula Weight
248.3
Purity
≥85%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
O=C1C2=CC(C)(C)[C@H](O)C2=C(C)C3(CC3)[C@]1(O)C
InChi Code
InChI=1S/C15H20O3/c1-8-10-9(7-13(2,3)12(10)17)11(16)14(4,18)15(8)5-6-15/h7,12,17-18H,5-6H2,1-4H3/t12-,14+/m1/s1
InChi Key
QVMDIQLUNODCTG-OCCSQVGLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $369

    Add

    5 mg

    $1,286

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA.1 It is cytotoxic to HL-60 human leukemia cells at 6-100 nM.2 Illudin M was used as a base structure for the development of potential anticancer agents with less toxicity and improved efficacy.3,1 It is closely related to illudin S (Item No. 17451), which has been the focus of additional studies.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jacobson, J.M., Feinman, L., Liebes, L., et al. Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John’s wort plant, in patients with chronic hepatitis C virus infection. Antimicrob. Agents and Chemother. 45(2), 517-524 (2001).

    2. Kelner, M.J., McMorris, T.C., Beck, W.T., et al. Preclinical evaluation of illudins as anticancer agents. Cancer Res. 47(12), 3186-3189 (1987).

    3. Schobert, R., Knauer, S., Seibt, S., et al. Anticancer active illudins: Recent developments of a potent alkylating compound class. Curr. Med. Chem. 18, 790-807 (2011).