An antitumor agent
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Duclauxin

Item No. 22068

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(8S,8aS,15aR,15bR,16S)-16-(acetyloxy)-8a,15a-dihydro-4,11-7H-8,15b-methano-1H,3H,12H-benzo[de]cyclohepta[1,2-g:3,4,5-d'e']bis[2]benzopyran-3,7,12,15(8H)-tetrone
CAS Number
1732-37-2
Synonyms
  • NSC 258308
Molecular Formula
C29H22O11
Formula Weight
546.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
OC1=CC(C)=C([C@]([C@@]([C@]2([H])OC(C)=O)([H])C(C3=C(C)C=C4O)=O)(OC)[C@@]5([H])[C@@]62C3=C4C(OC6)=O)C7=C1C(OC=C7C5=O)=O
InChi Code
InChI=1S/C29H22O11/c1-9-5-14(32)18-20-15(9)23(34)21-25(40-11(3)30)28(20,8-39-27(18)36)24-22(33)12-7-38-26(35)17-13(31)6-10(2)19(16(12)17)29(21,24)37-4/h5-7,21,24-25,31-32H,8H2,1-4H3/t21-,24+,25-,28-,29+/m0/s1
InChi Key
WBQDAYWQELBEPU-FKKRYKJISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $236

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    2.5 mg

    $1,053

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    Cayman Chemical
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    Product Description

    Duclauxin decreases proliferation of tumor cells in vitro and increases the lifespan of mice innoculated with Ehrlich ascitic tumor cells.1,2 Duclauxin (10-30 µg/ml) inhibits mitochondrial respiration of P-388 tumor cells and nucleic acid synthesis in cell culture of Ehrlich cancer, the lymphadenomas NK/LI and L 5178, and sarcoma 37.3,4 Duclauxin also inhibits growth of wheat coleoptile.5,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fusková, A., Proksa, B., and Fuska, J. In vitro effect of duclauxin and derivatives of coumarin on nucleic acid and protein synthesis in Ehrlich’s Ascites Carcinoma cells (EAC). Pharmazie 32(5), 291-293 (1977).

    2. Kawai, K., Nozawa, Y., Ito, T., et al. Effects of xanthomegnin and duclauxin on culture cells of murine leukemia and Ehrlich ascitic tumor. Res. Commun. Chem. Pathol. Pharmacol. 36(3), 429-438 (1982).

    3. Kovác, L., Böhmerová, E., and Fuska, J. Inhibition of mitochondrial functions by the antibiotics, bikaverin and duclauxine. J. Antibiot. (Tokyo) 31(6), 616-620 (1978).

    4. Fuska, L.A., Ivanitskaia, L.P., Makukho, L.V., et al. The effects of the antibiotics vermiculin PSX-1, bicaverin and duclauxin, isolated from fungi, on nucleic acid synthesis in several tumors. Antibiotiki 19(10), 33-37 (1974).

    5. Bryant, F.O., Cutler, H.F., and Jacyno, J.M. Properties and cost effective method for production of the antitumor agent declauxin from sporulating Penicillium herquei. J. Pharm. Sci. 82(12), 1214-1217 (1993).